（载脂蛋白表型及基因型的检测）参考文献

1.鄢盛恺，载脂蛋白（a）研究近况，国外医学临床生物化学与检验学分册，1996，7：38 2.Utermann,G.The,mysteries oflipoprotein(a).Science,1989,246:904 3.Utermann G,Menzel HJ,KraftHG,et al.Lp(a)glycoprotein phenotypes ,inheritance and relation toLp(a)lipoprotein concentratios in plasma.J Clin Invest,1987,80:458 4.Utermann G,Kraft HG,MenzelHJ,et al.Genetics of the quantitative Lp(a)lipoprotein trati.I.Relation tolp(a)glycoprotein phenotypes to Lp(a)lipoprotein concentrations in plasma.HumGenet,1988,78:41 5.Kraft HG,Dieplinger ,Hoye E,etal.Lp(a)phenotyping by immunoblotting with polyclonal and monoclonalantibodies.Arteriosclerosis,1988,8:212 6.Huang CM,Kraft HG,GreggRE,Modified immunoblotting technique for phenotyping lipoprotein (a),ClinChem,1991,37:576 7.Gaubtz JW,Ghanem KI,Geavara JJr,et al.Polymorphism of human apolipoprotein (a):Inhertance and relationshipof their molecular weights to plasma levels of lipoprotein(a).JlipidRes,1990,31:603 8.Kamboh MI ,Ferrell RE,KottkeBA.Expressed hypervariable polymorphism of apolipoprotein (a)Am J HumGenet.1991,49:1063 9.Getoldi D,Bellotti V,BuscagliaP,et al .Characterization of Apo(a) polymorphism by a modified immunoblottingtechnique in an Italian poprlation sample.Clin Chim Acta,1993,221:159 10.Marcovina SM,Zhang ZH,GaurVP,et al.Identification of 34apolipoprotein (a)siofoms:differential expressionof apolipoprotein(a) alleles between American blacks and whites.Biochem BiophysRes Commun,1993,191:1192 11.李建军，压一义，汪俊军，人血清脂蛋白（a）的多肽性检油，中华医学检测杂志，1994，17：22 12.Sandholzer C,boerwinkle E,SahaN,et al.Apolipoprotein(a)phenotypes,Lp(a) concentration and plasma lipid levelsin relation to coronary heart disease in a Chinese population ;evidence for therole of the Apo(a) gene in coronary heart disease.J Clin Invest,1992,89:1040 13.秦树存，王士雯，李成文等，载脂蛋白（a）多态性与冠心病的关系，中健医学杂志，1995，75：588 14.庄一义，李建军，汪俊军，心脑血管疾病患者载脂蛋白（a）多态性研究，中华医学杂志，1995，75：149 15.Pedro-Botet J,Senti M,AuguetT,et al.Apolipoprotein(a)genetic polymorphism and serumlipoprotein(a)concentration in paticnts with peripheral vascular disease.Atherosclerosis ,1993,104:87 16.Dieplinger H,Lackner,LacknerC,Kronenberg F,et al.Elevated plasma concentrations of lipoprotein(a) inpatients with end-stage renal disease are not related to the size polymorphismof apolipoprotein(a).J Clin Invest,1993,91:397 17.Utermann G,Jaeschke M,MenzelJ.Familial hyperlipoproteinemia type Ⅲ.Deficiency of a specificpaolipoprteins.FEBS Lett,1975,56:352 18.Rall SC Jr,WeisgraberKH,Mahley RW.Human apolipoprotein e heterogeneity cysteine-arginineinterchanges in the amino acid sequence of the ApoE isoforms.J Bio L Chem,1981,256:9077 19.Wardell MR,Suckling PA,JanusED.Genetic variation in human apolipoprotein E.J Lipid Res,1982,23:1174 20.Zannis VI,Breslow JL.Humanvery low density lipoprotein apolipoprotein isoprotein polymorphism isexplained by genetic vartion and post-translational modifications.Biochemistry,1981,20:1033 21.Davignon J,Gregg RE,SingCF.Apolipoprotein E polymorphism and atherosclerosis.Arteriosclerosis,1988,8:11 22.解用虹，何锦林，王克勤，载脂蛋白E异构体的分离及其表型测定，生物化学与生物物理学报，1987，19：272 23.王克勤，解用虹，何锦麟。中国人群（京津地区）载脂蛋白E基因多态性和表型分布的研究，生物化学杂志1988，4：274 24.Utemann G,Steinmetz A,WeberW.Genetic control of human apolipoprotein E polymorphism:Comparison of one andtwo dimensional techniques of isoprotein analysis. Hum Genet,1982,60:34 25.吕新跃，陈保生，薜红等。微量血清等电聚焦电泳及免疫印这类法测定人载脂蛋白E表型，中华医学检验杂志，1994，17：26 26.牛庆田，国汉帮，山村卓等，免疫印迹法测定血清载脂蛋白E的表型，中华医学检验杂志，1994，17：16 27.Havekes LM,De KnijffP,Beisiegel V,et al.Arapid micromethod for apolipoprotein E phenotypingdirectly in serum.J Lipid Res,1987,28:455 28.Kataoka,S,Paidi M,HowardBV,Simplified isoelectric focusing/immunoblotting determination ofapolipoprotein E phenotype.Clin Chem,1944,40:11 29.Scana AM,EdelsteinC.Solubility in aqueous solution of ethjenol of thems all molecular weightpeptides of the serum VLDL and HDL.Anal Biochem,1971,44:576 30.Menzel HJ,Kladetsky RG,Assmann G,Apoprotein Epolymorphism and coronary arterydisease.Arteriosclerosis,1983,3:310 31.Siest G,Pillot T,Regis-BaillyA,et al .Apoliprotein E:An important gene and protein to follow in laboratorymedicine.Clin Chem,1995,41:1068 32.Yamamura T,YamamotoA,Sumiyoshi T,et al.New mutants of apolipoprotein E associated withatherosclerotic disease but not to type Ⅲhyperlipoproteinemia .J ClinInvest,1984,74:1229 33.Cumming AM,RobertsonF.Polymorphism at the apolipoprotein Elocus in relation to risk of coronarydisease.Clin Genet ,1984,25:310 34.Sing CF.Davignon,J.Role of theapolipoprotein e polymorphism in determing mormal plasma lipid and lipoproteinvariation Am J Hum Genet,1985,37:268 35.Borwinkle E,Visvkis S,WelshD,et al.The use of measured genotype information in the analysis of quanitationphenotypes in man.Am J Hum Genet.1987,27:567 36.Ehnholm C,Lukka M,Kuusi T,etApolipoprotein E polymorphism in the Finish poprlation ;gene frequencies andrelation to lipoprotein concentrations.J Lipid Res,1986,27:227 37.Ghiselli G,Schaefer EJ,ZechLA,et al.Increased prevalence of apolipoprotein E4,in type V hyperlipoproteinemia.J Clin Invest,1982,70:474 38.Utermann G.Apolipoprotein Epolymorphism in healyty and disease.Am Heart J,1987,113:433 39.Pedro-Botet J,Senti(a),triglyceride-rich lipoproteins and apolipoprotein Epolymorphism.Stroke,1992,23:1556 40.Couderc R,Mahieuk F,BailleulS,et al.Prevalence of apolipoprotein E phenotypes in ischemic cerebrovasculardisease:A case-control study.Stroke,1993,24:661 41.Shimano H,Ishibashi S,MuraseT,et al.Plasma apolipoproteins in patients with multiinfarctdementia.Atherosclerosis,1989,79:257 42.Strittmatter WJ,SaundersAM,Schmechel D,et al.Apolipoprotein E:High-avdity blinding to beta-amyloid andincreased frequency of type 4 allele in late-ornset familial Alzheimerdisease.Proc Natl Acad Sci USA,1993,90:1977 43.Schachter F,Faure-DelanefL,Guenot F,et al .Genetic assocations with human longevity at the AopE and ACEloci.Nat Gengt,1994,6:29 44.Shoulders CC,Ball MJ,MannJI,et al.Genetic marder in apolipoprotein AI/CⅢgene complex associated withhypercholwseterlemia.Lancet,1986,11:1286 45.Ordovas J,Civeira F,GenestJJr,et al.Restriction fragment length polymorphisms of the apolipoproteins ,andpremature coronary disease.Atherosclerosis,1991,87:75 46.Yang CY,Gu ZW,Weng S,etal.Structure of apolipoprotein B—100 of human low densitylipoproteins.Arteriosclerosis,1989,9:96-108 47.Boerwinkle E,lee SS,Balter Ret al.Rapid typing of apolipoprotein B DNA polymorphism by DNaamplification.Atherosclerosis,1990,81:115-232 48.Soria LF,Ludwig EH ,ClarkeHRG,et al.Association between a specific apolipoprotein B mutation and familialdefective apoprotein B-100 Pro Natl Acad Sci USA,1989,96:587-591 49.Priestley,Knott T,Wallis S,etal.RFLP for the humam apolipoprotein B gene V:Xba I,Nucleic AcidsRes,1985,13:6793 50.Wu H,Wen MS,Lo SK,et al.DNApolymorphisms of apolipoprotein Bin the population of Taiwan.J Formos MedAssoc,1993,92:330-335 51.Young SG,Recent progress inunderstanding apolipoproteinB,Circulation,1990,82:1574-1579 52.Boerwinkle E,Xiong W.FourestE,et al Rapid typing of tandemly repeated hypervariable loci by the polymerasechain reaction :Application to the apolipoprotein B3 hypervariable region.ProcNatl Acad Sci USA 1989,86:212-216 53.Hixon JE,PK,McMahan CA,etal.The human apolipoprotein B3hypervariable region :detection of eight newalleles and comparisons of allele frequencies in blcks and whites.HumGenet,1993,91:475-479 54.Friele W,Ludwig EH,PaulweberB,et al.Hypervariability in a minisatellite3 of the apoipoprotein B gene inpatients with coronary heart disease compared with normal controls.J LipidRes,1990,31:659-665 55.Borwinkle E,chan L.Athreecodon insertion /deletion polymorphism in the signal peptide region of thehuman apolipoprotein B gene directly typed by the popymerade chain reactionNucleic Acids Res,1989,17:4003 56.Wu JH,Wen MS,Lo SK,etal.Increased frequency of apolipoprotein B signal peptede SP 24/24 in patentswith coronary artery disease.General allele surey in the population of Taiwanand comparison with caucasians,Clin Genet,1994,45:250-254 57.Renges HH,Wile DB,MckeigueDM,et al.Apolipoprotein B gene polymorphisms are associated with lipid levelsin men of South Asian descent.Atheroscleosis,1991,91:267-275 58.Peacock R,Dunning A,HamstenA,et al.Apolipoprotein B gene polymorphisms,lipophisms ,lipoproteins andatherosclerosis:a study of young mycardial infarction survivors and healyhypoprlation base indivduals.Atherosclerosis,1992,92:151-164 59.Saha W,Tong MC,Tay JS,etal.DNA polymorphisms of the apolipoprotein B gene in Chinese artery diseasepatients ,Clin Genet,1992,42:164-170 60.Loparev VN,Cartas MA,MonkenCE,et al.An efficient and simple method of DNA extraction from whole bolod andcell line to identify infectious agents .J Virol Methods ,1991,34:105-112 61.周新，甘佩珍，杨香玖等，健康成人与Ⅱ型糖尿病人ApoE遗传表型，武汉大学学报生物工程专利，1990，109-112 62.涂建成，周新，哈黛文等，聚合酶链反应技术检测ApoE基因型，中国病理生理杂志，1997，65 63.况少青，金桦，陈保生等，高脂血症患儿载脂蛋白AI-CⅢ基因限制性片段长度多态性研究，中华医学检验杂志，1994，17：19-21 64.鄢盛恺，周新，哈黛文等，聚合酶链反应限制性片段长度多态性检测ApoE基因型，中华医学检验杂志，1997，20：28-31